Nanoparticle PBPK model
This package contains a physiologically-based pharmacokinetic (PBPK) model, based on a publication by Dong et al. The accompanying code can be used to:
* Calculate confidence intervals on parameter estimates and model predictions (SimBiology functions: sbioparameterci, sbiopredictionci)
* Perform noncompartmental analysis (NCA) on PK datasets, as well as model predictions to obtain clinically relevant parameters (SimBiology function: sbionca)
* Illustrate justifications for using parallel computing such as dealing with out-of-memory simulations and increasing performance by introducing MATLAB functions and how they work in conjunction with SimBiology (MATLAB functions: datastore, parfor, mapreduce)
This model and code were also discussed in the following webinar:
http://www.rosaandco.com/webinars/2017/enabling-qsp-and-pk-pd-workflows-using-simbiology-and-matlab-whats-new
Reference:
Model based on:
"Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112”
Dong D et al.
International Journal of Nanomedicine, 2015 Volume 10, 2521-2535.
Citar como
MathWorks SimBiology Team (2024). Nanoparticle PBPK model (https://www.mathworks.com/matlabcentral/fileexchange/64988-nanoparticle-pbpk-model), MATLAB Central File Exchange. Recuperado .
Compatibilidad con la versión de MATLAB
Compatibilidad con las plataformas
Windows macOS LinuxCategorías
Etiquetas
Comunidades de usuarios
Community Treasure Hunt
Find the treasures in MATLAB Central and discover how the community can help you!
Start Hunting!Descubra Live Editor
Cree scripts con código, salida y texto formateado en un documento ejecutable.
1_CIs/
2_NCA/
3_Parallel/
Versión | Publicado | Notas de la versión | |
---|---|---|---|
1.0.0.0 | Updated reference |