This Matlab code estimates the bolus arrival time (BAT) of DCE-MRI signals. It is particularly intended to work with signals that do not have a fast upslope as it is often the case for data of small animals. The proposed method employs a spline-based approximation model. Parameter estimation is done by generalized cross validation.
A. Bendinger, C. Debus, C. Glowa, C. Karger, J. Peter, M. Storath, "Bolus arrival time estimation in dynamic contrast-enhanced MRI of small animals based on spline models". 2018