How to do Bayesian Parameter Estimation using Optimization in Simbiology
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Andy
el 27 de Jun. de 2017
Respondida: Andy
el 2 de Jul. de 2017
Hello Matlab Community, I have a one-compartment pharmacokinetic model with the following parameters: Ka=0.8 (1/Hour), CL=26 (Liters/Hour), Vd=947 (Liters).
I am administering is 10mg every 24-hours 14-days = 336-hours.
What I would like to do is to add in a trough plasma concentration at 14-days of 40ng/mL.
What I would like to see if Simbiology can do is to estimate the Clearance Rate (CL) alone by keeping the Ka and Vd fixed at time=336hours and concentration=40ng/mL.
I can do this manually, by adjusting the Clearance Rate parameter, but I was looking to see if this may be automated to fit the data-point or concentration at time point 336hours of 40ng/mL. Thus, time=336, concentration=40ng/mL.
Thanks for your help.
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Arthur Goldsipe
el 28 de Jun. de 2017
The SimBiology documentation describes different ways to estimate parameters in a model. Does that help?
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