Pure Inter Covariance for Coronavirus Variants

Pure Inter Covariance is the arithmetic average of variances minus inter covariance, it represents the nonlinear distance between variants.

The analysis results of spike protein from Wuhan strain SARS-CoV-2 in comparison with spike proteins from SARS-CoV-2 variants. The peaks and the dips in the graphs represent variations in Mass-Charge ratio of the amino acids of the spike proteins, meaning that mutations occur in this region resulting in changes in charge/mass of the amino acids. The wider peaks or dips represent the changes involved in more amino acid changes of the spike proteins. The peaks indicate positive correlation and the dips indicate negative correlation. The dips mean opposite changes in the charge/mass of the amino acids of the spike proteins. The dips may have stronger impact on the biological function of the proteins than the peaks.