How can I use regression in MATLAB and estimate some parameters of my model which is exported from COMSOL software?

I have a .m file from COMSOL software. I want to modify some variables by regression with experimental data. I was wondering if there is a solution for that.

[dpb]

Of course, :) --but more info needed for specifics...

But, you can start with

doc polyfit % and friends

The Statistics and Curve Fitting toolboxes have many other builtin functions; lacking those you can write general explicit models and solve via the backslash operator, see

doc ldivide