HeartModelPub

This project includes a library of cardiac electrical models for evaluating and testing cardiac devices in a closed-physiologic loop.

This project includes pacemaker cell models [1], cardiomyocytes [2,3], the cardiac conduction system [3] and EGM generation [4], which are implemented in Matlab/Simulink. We have demonstrated the in-silico validation of a DDD mode pacemaker with the virtual physiological heart model in the closed-loop [5]. For C code generation and implementation using Piha, please refer to [6][7].

The complete original models were presented in the following papers:

[1] Ai, Weiwei, et al. "A parametric computational model of the action potential of pacemaker cells." IEEE Transactions on Biomedical Engineering 65.1 (2017): 123-130.

[2] Yip, Eugene, et al. "Towards the emulation of the cardiac conduction system for pacemaker validation." ACM Transactions on Cyber-Physical Systems 2.4 (2018): 32.

[3] Ai, Weiwei, et al. "Cardiac electrical modeling for closed-loop validation of implantable devices." IEEE Transactions on Biomedical Engineering 67.2 (2019): 536-544.

[4] Ai, Weiwei, et al. "An intracardiac electrogram model to bridge virtual hearts and implantable cardiac devices." 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2017.

[5] Ai, Weiwei, et al. "Closing the loop: Validation of implantable cardiac devices with computational heart models." IEEE journal of biomedical and health informatics 24.6 (2019): 1579-1588.

[6] Allen, Nathan, et al. "Modular code generation for emulating the electrical conduction system of the human heart." Proceedings of the 2016 Conference on Design, Automation & Test in Europe. EDA Consortium, 2016.

[7] Malik, Avinash, et al. "Modular compilation of hybrid systems for emulation and large scale simulation." ACM Transactions on Embedded Computing Systems (TECS) 16.5s (2017): 118.

When using these models, please cite the original publications.

This repository provides running examples showing:

A) Cardiac cell model simulation: SAcell.slx, CNcell.slx, HPScell.slx, AV.slx;

B) Cardiac conduction system (heart model) simulation: HeartExe.slx; and

C) The closed-loop device testing using the heart model: CLSfixed.slx.

For model descriptions, please refer to the Readme.txt.