Yes, you can run a long Matlab program that takes several days on a laptop with the lid closed, provided you adjust your power settings appropriately. Keep your laptop plugged in to a power source and take care of laptop heat.
Also, analyze the memory requirements before running the code, as they may slow down the execution later. You can through this stack overflow link.
Please note that it’s generally more suitable to run such long and intensive computations on a desktop or a server, which are designed to handle sustained high loads better than laptops. If you frequently need to run such long tasks, you might want to consider using a powerful machine or cloud-based solutions.
