PBPK model construction for radioactive probe drugs

Dear all,

I am trying to build a PBPK model of a radioactive probe, and the proposed drug dose unit is Bq (becquerel), but the becquerel unit in current simbiology is not a drug dose category. The error is as follows：Quantity named Dose_Central references a unit that dose not exist or is not a valid unit.

In addition, do you have any experience in building PBPK models of radioactive probes? If so, can you share it?

Thanks！

Miya

Answer 1

[Arthur Goldsipe]

Please read the following other posts to understand the constraints on species units:

• Can I use "mL/kg" and "mg/kg" for compartment and species units in SimBiology?
• Any progress on relaxing the constraints on species units?

I'll add the use case of radioactive probes to our enhancement database. If you or anyone else has example models they can share, it would also help the SimBiology development team better understand how to support this kind of modeling.

[敏]

Thanks for your answer！Could you please share the link to the enhancement database? Thank you very much!

[Arthur Goldsipe]

This enhancement database is internal to MathWorks. So there is no link I can share.